Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study
Identifieur interne : 001133 ( Main/Corpus ); précédent : 001132; suivant : 001134Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study
Auteurs : Flavio Nobili ; Giovanni Abbruzzese ; Silvia Morbelli ; Roberta Marchese ; Nicola Girtler ; Barbara Dessi ; Andrea Brugnolo ; Cinzia Canepa ; Giorgos Chr. Drosos ; Gianmario Sambuceti ; Guido RodriguezSource :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
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Abstract
The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22381
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Martino University Hospital, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morbelli, Silvia" sort="Morbelli, Silvia" uniqKey="Morbelli S" first="Silvia" last="Morbelli">Silvia Morbelli</name><affiliation><mods:affiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Marchese, Roberta" sort="Marchese, Roberta" uniqKey="Marchese R" first="Roberta" last="Marchese">Roberta Marchese</name><affiliation><mods:affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. 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Martino University Hospital, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name><affiliation><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8FA3710E7F523201F4933EE2C81D90BA25CD5E52</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22381</idno><idno type="url">https://api.istex.fr/document/8FA3710E7F523201F4933EE2C81D90BA25CD5E52/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001133</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study</title><author><name sortKey="Nobili, Flavio" sort="Nobili, Flavio" uniqKey="Nobili F" first="Flavio" last="Nobili">Flavio Nobili</name><affiliation><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name><affiliation><mods:affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morbelli, Silvia" sort="Morbelli, Silvia" uniqKey="Morbelli S" first="Silvia" last="Morbelli">Silvia Morbelli</name><affiliation><mods:affiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Marchese, Roberta" sort="Marchese, Roberta" uniqKey="Marchese R" first="Roberta" last="Marchese">Roberta Marchese</name><affiliation><mods:affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Girtler, Nicola" sort="Girtler, Nicola" uniqKey="Girtler N" first="Nicola" last="Girtler">Nicola Girtler</name><affiliation><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Dessi, Barbara" sort="Dessi, Barbara" uniqKey="Dessi B" first="Barbara" last="Dessi">Barbara Dessi</name><affiliation><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Brugnolo, Andrea" sort="Brugnolo, Andrea" uniqKey="Brugnolo A" first="Andrea" last="Brugnolo">Andrea Brugnolo</name><affiliation><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Canepa, Cinzia" sort="Canepa, Cinzia" uniqKey="Canepa C" first="Cinzia" last="Canepa">Cinzia Canepa</name><affiliation><mods:affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Drosos, Giorgos Chr" sort="Drosos, Giorgos Chr" uniqKey="Drosos G" first="Giorgos Chr." last="Drosos">Giorgos Chr. Drosos</name><affiliation><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Sambuceti, Gianmario" sort="Sambuceti, Gianmario" uniqKey="Sambuceti G" first="Gianmario" last="Sambuceti">Gianmario Sambuceti</name><affiliation><mods:affiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name><affiliation><mods:affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-02-15">2009-02-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="414">414</biblScope><biblScope unit="page" to="421">421</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8FA3710E7F523201F4933EE2C81D90BA25CD5E52</idno><idno type="DOI">10.1002/mds.22381</idno><idno type="ArticleID">MDS22381</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>amnestic mild cognitive impairment</term><term>brain SPECT, SPM</term><term>mild cognitive impairment</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Flavio Nobili MD</name><affiliations><json:string>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Giovanni Abbruzzese MD</name><affiliations><json:string>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Silvia Morbelli MD</name><affiliations><json:string>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Roberta Marchese MD</name><affiliations><json:string>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Nicola Girtler PsyD</name><affiliations><json:string>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Barbara Dessi PsyD</name><affiliations><json:string>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Andrea Brugnolo PsyD</name><affiliations><json:string>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Cinzia Canepa MD,</name><affiliations><json:string>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Giorgos Chr. Drosos MD</name><affiliations><json:string>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Gianmario Sambuceti MD</name><affiliations><json:string>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Guido Rodriguez MD</name><affiliations><json:string>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mild cognitive impairment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>amnestic mild cognitive impairment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>brain SPECT, SPM</value></json:item></subject><articleId><json:string>MDS22381</json:string></articleId><language><json:string>eng</json:string></language><abstract>The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P > 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P > 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>7.726</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1713</abstractCharCount><pdfWordCount>4894</pdfWordCount><pdfCharCount>32933</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>236</abstractWordCount></qualityIndicators><title>Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>421</last><first>414</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22381</json:string></doi><id>8FA3710E7F523201F4933EE2C81D90BA25CD5E52</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8FA3710E7F523201F4933EE2C81D90BA25CD5E52/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8FA3710E7F523201F4933EE2C81D90BA25CD5E52/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8FA3710E7F523201F4933EE2C81D90BA25CD5E52/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Contributor Roles: Flavio Nobili: Conception and organization of the research project; writing the first manuscript draft. Giovanni Abruzzese: Conception and organization of the research project; review and critique of the manuscript draft. Silvia Morbelli: Design and execution of SPECT statistical analysis. Roberta Marchese: responsibility for patient selection, visit, interview and enrollment; review and critique of the manuscript draft. Nicola Girtler: methods: statistical analysis of neuropsychological data. Barbara Dessi: execution of the research project, mainly neuropsychological assessment. Andrea Brugnolo: review and critique of statistical analysis on neuropsychological data. Cinzia Canepa: patient salection, visit, interview and enrollment. Giorgos Chr. Drosos: review and critique of manuscript draft. Gianmario Sambuceti: supervising SPECT acquisition; SPECT technical quality control. Application of the EANM guidelines. Guido Rodriguez: Conception and organization of the research project; review and critique of the manuscript.</note><note type="content">*Potential conflict of interest: None reported.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study</title><author><persName><forename type="first">Flavio</forename><surname>Nobili</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Clinical Neurophysiology (DiSEM), University of Genoa, Viale Benedetto XV,6, I‐16132 Genoa, Italy</p></note><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation></author><author><persName><forename type="first">Giovanni</forename><surname>Abbruzzese</surname></persName><roleName type="degree">MD</roleName><affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</affiliation></author><author><persName><forename type="first">Silvia</forename><surname>Morbelli</surname></persName><roleName type="degree">MD</roleName><affiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</affiliation></author><author><persName><forename type="first">Roberta</forename><surname>Marchese</surname></persName><roleName type="degree">MD</roleName><affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</affiliation></author><author><persName><forename type="first">Nicola</forename><surname>Girtler</surname></persName><roleName type="degree">PsyD</roleName><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation></author><author><persName><forename type="first">Barbara</forename><surname>Dessi</surname></persName><roleName type="degree">PsyD</roleName><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation></author><author><persName><forename type="first">Andrea</forename><surname>Brugnolo</surname></persName><roleName type="degree">PsyD</roleName><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation></author><author><persName><forename type="first">Cinzia</forename><surname>Canepa</surname></persName><roleName type="degree">MD,</roleName><affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</affiliation></author><author><persName><forename type="first">Giorgos Chr.</forename><surname>Drosos</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation></author><author><persName><forename type="first">Gianmario</forename><surname>Sambuceti</surname></persName><roleName type="degree">MD</roleName><affiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</affiliation></author><author><persName><forename type="first">Guido</forename><surname>Rodriguez</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-02-15"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="414">414</biblScope><biblScope unit="page" to="421">421</biblScope></imprint></monogr><idno type="istex">8FA3710E7F523201F4933EE2C81D90BA25CD5E52</idno><idno type="DOI">10.1002/mds.22381</idno><idno type="ArticleID">MDS22381</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>mild cognitive impairment</term></item><item><term>amnestic mild cognitive impairment</term></item><item><term>brain SPECT, SPM</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-04-09">Received</change><change when="2008-10-09">Registration</change><change when="2009-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8FA3710E7F523201F4933EE2C81D90BA25CD5E52/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/mds.v24:3</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2009-02-15">15 February 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="140" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22381</doi><idGroup><id type="unit" value="MDS22381"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2008 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-04-09"></event><event type="manuscriptRevised" date="2008-10-08"></event><event type="manuscriptAccepted" date="2008-10-09"></event><event type="firstOnline" date="2008-11-17"></event><event type="publishedOnlineFinalForm" date="2009-02-23"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2008-11-17"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.3.0 mode:FullText" date="2014-04-14"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.0 mode:FullText" date="2014-04-14"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">414</numbering><numbering type="pageLast">421</numbering></numberingGroup><correspondenceTo>Clinical Neurophysiology (DiSEM), University of Genoa, Viale Benedetto XV,6, I‐16132 Genoa, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22381.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="47"></count><count type="wordTotal" number="6727"></count></countGroup><titleGroup><title type="main" xml:lang="en">Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study<link href="#fn1"></link> <link href="#fn2"></link></title><title type="short" xml:lang="en">SPECT in PD‐MCI</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Flavio</givenNames><familyName>Nobili</familyName><degrees>MD</degrees></personName><contactDetails><email>flaviomariano.nobili@hsanmartino.it</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Giovanni</givenNames><familyName>Abbruzzese</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Silvia</givenNames><familyName>Morbelli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Roberta</givenNames><familyName>Marchese</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Nicola</givenNames><familyName>Girtler</familyName><degrees>PsyD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Barbara</givenNames><familyName>Dessi</familyName><degrees>PsyD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Andrea</givenNames><familyName>Brugnolo</familyName><degrees>PsyD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Cinzia</givenNames><familyName>Canepa</familyName><degrees>MD,</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Giorgos Chr.</givenNames><familyName>Drosos</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Gianmario</givenNames><familyName>Sambuceti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Guido</givenNames><familyName>Rodriguez</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">mild cognitive impairment</keyword><keyword xml:id="kwd3">amnestic mild cognitive impairment</keyword><keyword xml:id="kwd4">brain SPECT, SPM</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22381:TABLEA"></mediaResource><caption>TABLE A. Numerical results of SPM comparison ‘PD minus PD‐MCI patients’</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22381:TABLEB"></mediaResource><caption>TABLE B. Numerical results of SPM comparison ‘PD‐MCI minus aMCI patients’</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22381:FigureA"></mediaResource><caption>FIGURE A. Results of SPM2 comparison between PD patients and patients with PD‐MCI</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22381:FigureB"></mediaResource><caption>The reverse comparison between patients with PD‐MCI and aMCI</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22381:suppfiglegends"></mediaResource><caption>Full legends to Figures A and B</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (<i>P</i> < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected <i>P</i> < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Contributor Roles: Flavio Nobili: Conception and organization of the research project; writing the first manuscript draft. Giovanni Abruzzese: Conception and organization of the research project; review and critique of the manuscript draft. Silvia Morbelli: Design and execution of SPECT statistical analysis. Roberta Marchese: responsibility for patient selection, visit, interview and enrollment; review and critique of the manuscript draft. Nicola Girtler: methods: statistical analysis of neuropsychological data. Barbara Dessi: execution of the research project, mainly neuropsychological assessment. Andrea Brugnolo: review and critique of statistical analysis on neuropsychological data. Cinzia Canepa: patient salection, visit, interview and enrollment. Giorgos Chr. Drosos: review and critique of manuscript draft. Gianmario Sambuceti: supervising SPECT acquisition; SPECT technical quality control. Application of the EANM guidelines. Guido Rodriguez: Conception and organization of the research project; review and critique of the manuscript.</p></note><note xml:id="fn2"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SPECT in PD‐MCI</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study</title></titleInfo><name type="personal"><namePart type="given">Flavio</namePart><namePart type="family">Nobili</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation><description>Correspondence: Clinical Neurophysiology (DiSEM), University of Genoa, Viale Benedetto XV,6, I‐16132 Genoa, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Abbruzzese</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Silvia</namePart><namePart type="family">Morbelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberta</namePart><namePart type="family">Marchese</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicola</namePart><namePart type="family">Girtler</namePart><namePart type="termsOfAddress">PsyD</namePart><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara</namePart><namePart type="family">Dessi</namePart><namePart type="termsOfAddress">PsyD</namePart><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrea</namePart><namePart type="family">Brugnolo</namePart><namePart type="termsOfAddress">PsyD</namePart><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cinzia</namePart><namePart type="family">Canepa</namePart><namePart type="termsOfAddress">MD,</namePart><affiliation>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giorgos Chr.</namePart><namePart type="family">Drosos</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gianmario</namePart><namePart type="family">Sambuceti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guido</namePart><namePart type="family">Rodriguez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-02-15</dateIssued><dateCaptured encoding="w3cdtf">2008-04-09</dateCaptured><dateValid encoding="w3cdtf">2008-10-09</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">47</extent><extent unit="words">6727</extent></physicalDescription><abstract lang="en">The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society</abstract><note type="content">*Contributor Roles: Flavio Nobili: Conception and organization of the research project; writing the first manuscript draft. Giovanni Abruzzese: Conception and organization of the research project; review and critique of the manuscript draft. Silvia Morbelli: Design and execution of SPECT statistical analysis. Roberta Marchese: responsibility for patient selection, visit, interview and enrollment; review and critique of the manuscript draft. Nicola Girtler: methods: statistical analysis of neuropsychological data. Barbara Dessi: execution of the research project, mainly neuropsychological assessment. Andrea Brugnolo: review and critique of statistical analysis on neuropsychological data. Cinzia Canepa: patient salection, visit, interview and enrollment. Giorgos Chr. Drosos: review and critique of manuscript draft. Gianmario Sambuceti: supervising SPECT acquisition; SPECT technical quality control. Application of the EANM guidelines. Guido Rodriguez: Conception and organization of the research project; review and critique of the manuscript.</note><note type="content">*Potential conflict of interest: None reported.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>mild cognitive impairment</topic><topic>amnestic mild cognitive impairment</topic><topic>brain SPECT, SPM</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: TABLE A. Numerical results of SPM comparison ‘PD minus PD‐MCI patients’ - TABLE B. Numerical results of SPM comparison ‘PD‐MCI minus aMCI patients’ - FIGURE A. Results of SPM2 comparison between PD patients and patients with PD‐MCI - The reverse comparison between patients with PD‐MCI and aMCI - Full legends to Figures A and B - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>414</start><end>421</end><total>8</total></extent></part></relatedItem><identifier type="istex">8FA3710E7F523201F4933EE2C81D90BA25CD5E52</identifier><identifier type="DOI">10.1002/mds.22381</identifier><identifier type="ArticleID">MDS22381</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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